消疲怡神口服液抗应激的实验研究──对强制冷水游泳应激大鼠行为及神经内分泌的影响

Effects of XiaoPiYiShen Oral Fluid On Rat Behavior and Neuro Endocrine System Under Forced Cold Water Swimming Conditions

通过强制冷水游泳应激模拟慢性疲劳的发病过程。结果表明，强制冷水游泳应激使大鼠自发活动减少，出现抑郁倾向，力竭游泳时间缩短，体力下降，血清中肾上腺素（Ｅ）、多巴胺（ＤＡ）、５羟色胺（５ＨＴ）含量升高，肾上腺抗坏血酸含量降低，这些与慢性疲劳患者症状表现和实验室检查结果相似。以补气理气、调理肝脾为组方原则的中药复方“消疲怡神口服液”可以调节上述变化，表明其具有抗应激、抗疲劳作用，同时该结果还为研究中医气机失调、肝脾失和与应激。

To assess whether the repeated force cold water swimming (RFCS) conditions influences the occurrence of chronic fatigue and the functional mechanism of the oral fluid of XiaoPiYiShen(XPYS), changes of behavior and neuroendocrine system in rats were examined. Results show that RFCS inhibit spontaneous activities in open field tests, shorten exhausted spontaneuous activities in open field tests, shorten exhausted swimming time in normal temperature water, increase epinephrine(E), dopamine(DA) and 5hydroxytryptamine(5HT) levels in serum and decrease ascorbic acid levels in adrenal gland. Those indicate that this animal model is helpful for further research of chronic fatigue. XPYS could reverse the changes caused by RFCS. That suggests XPYS has antistress and antifatigue function. It also benefits the study of relationship between the disorder of Qi, liver, spleen (TCM) and the stress and the chronic fatigue.