血清β-葡萄糖醛酸酶测定对肝脏肿瘤的临床意义

Detection of Serum β glucuronidase in Patients with Liver Diseases and Its Clinical Significance

目的：探讨血清β葡萄糖醛酸酶（βＧ）活性测定对肝脏肿瘤的临床意义。方法：建立ＥＬＩＳＡ技术测定肝癌与不同疾病患者血清中βＧ活性，并对肝癌患者治疗前后血清βＧ活性变化规律进行研究。结果：肝癌患者血清中βＧ活性明显高于肺癌，胃癌，甲状腺癌；也明显高于肝血管瘤，肝硬化等肝脏良性病变，均为Ｐ＜００１；肝癌患者手术切除治疗及介入治疗后血清βＧ活性明显降低，Ｐ＜００１；而肝癌复发时βＧ活性又有增高趋势。结论：作为一种体内酶标志，βＧ对肝癌的诊断。

Objective:To study the value of serum β Glucuronidase(β G) detection in the hepatic carcinoma diagnosis.Methods:We establish the ELISA method to detect the serum activity of β G in patients of liver cancer and patients suffered from various kinds of tumour diseases,and clear the change of serum β G in patients of hepatic carcinoma before and after treatment.Results:The serum β G activity of hepatocellular carcinoma patients was significantly higher than that in lung cancer and stomach cancer and thyroid carcinoma.And it was significantly higher than that in liver cirrhosis and hepatoangioma ( P <0 01).The serum β G level decreased markedly ( P <0 01) after operation or interrenien therapy.The activity of β G was significantly higher after relapse.Conclusion:As a marker of enzyme,β G appears to be helpful in diagnosis,treatment and prognosis of hepatocellular carcinoma.