CD_3AK细胞配合放疗治疗鼻咽癌的初步观察

Study on the effect of the combination of radiotherapy and CD3AK cells treatment on NPC

目的：观察ＮＰＣ放疗中配合用ＣＤ３ＡＫ细胞治疗的效果。方法：将ＮＰＣ分两组：Ａ组７２例（放疗＋ＣＤ３ＡＫ细胞治疗），Ｂ组９７例（单纯放疗）。治疗前后分别记录肿瘤情况，急性放射反应，Ｋａｒｎｏｆｓｋｙ氏评分，并检测外周血Ｔ淋巴细胞亚群和血清ＥＢ－ＶＣＡ－ＩｇＡ抗体水平。结果：①Ａ、Ｂ二组肿瘤消除率分别是９１．６７％、８７．６３％，ＥＢ－ＶＣＡ－ＩｇＡ降低者分别占７８％、６９％。Ａ、Ｂ组两项指标比较均无显著性差异（Ｐ＞０．０５）；②急性放射反应Ａ组明显比Ｂ组轻（Ｐ＜０．０１），Ｋａｒｎｏｆｓｋｙ氏评分Ａ组比Ｂ组有所改善（Ｐ＜０．０５）；③免疫指标：Ａ组的ＣＤ＋８比值下降，ＣＤ＋３、ＣＤ＋４、ＣＤ＋４／ＣＤ＋８比值均明显升高，而Ｂ组变化不大。结论：ＣＤ３ＡＫ细胞配合放疗治疗ＮＰＣ安全可靠，与放疗有相加（协同）作用，可明显减轻急性放射反应，并有提高患者免疫功能的作用。

Objective:To observe the effect of the combination of radiotherapy and CD3AK cells treatment on NPCMethods:Clinical trial was conducted in 169 patients with NPC divided into group A(72 cases treated with radiotherapy+CD3AK)and group B(97 cases treated with only radiotherapy)Before and after the treatment,the conditions of the cases and their acute reaction to radiation were recorded,Karnofsky's was used in the evaluation,and peripheral blood T cell subsets and the levels of EBVCAIgA were determinedResults:1The improvement rate were 9167% and 8763% respectively,and 78% and 69% of the patients showed reduction in EBVCAIgAThere was no significant difference between group A and group B(P>005)2The acute reaction to radiation of group A was significantly stronger than that of group B(P<001)Karnofsky's showed that group A had better improvement than group B(P<005)3Immunological index:Group A's CD+8 ratio decreased while its ratios of CD+3CD+4CD+4/CD+8 increases significantly,little difference was shown in group BConclusion:Treatment with combination of CD3AK and radiotherapy proved safe and effective for NPCThe combination could reduce acute reaction to radiation and enhance patients' immunity