标记木菠萝凝集素对大肠癌的鉴别性诊断

Differential diagnosis between colonitis and carcinoma of colon by labeled lectin

目的：探讨木菠萝凝集素在临床上的应用。方法：本文采用辣根过氧化物酶（ＨＲＰ）标记木菠萝凝集素，用亲和组织化学的方法，观察８０例结肠炎及结肠癌患者肠粘膜组织中凝集素受体的标记阳性率。结果：肠炎阳性率为２７．５％，肠癌为８２．５％，肠癌的凝集素受体阳性率显著高于肠炎（Ｐ＜０．０１）。结论：提示用亲和组织化学法检测肠粘膜中木菠萝凝集素受体可作为鉴别结肠癌、肠炎的一种辅助诊断措施。

Objective:to study clinical application of jacalinMethods:lectin receptors in human colonitis and carcinoma of colon tissues were studied by jacalinHRP using the affinitive histochemistry techniqueResults:The postitive rates of jacalin receptors in colonitis and carcinoma of colon were 275% and 825% respectivelyThe lectin receptors in carcinoma of colon were much higher than that in colonitis(P<0005)Conclusion:There is a helpful method to differentiate colonitis and carcinoma of colon by determining jacalinreceptors using the affinitive histochemistry technique