摘要
目的研究清脑醒神贴中挥发性成分的包合工艺。方法以均匀设计试验法设计β-环糊精包合工艺,采用气相色谱法测定包封率。优选多种高分子材料制备,浇铸制成贴片。结果完成了关键技术包合工艺的研究,确定最佳工艺为:β-环糊精与药物最佳包合比例为5:1,80℃恒温水浴搅拌60min进行包封。用浇铸法制备出新型凝胶骨架型中药控释穴位贴片。结论本制备工艺科学合理,具有良好的开发应用前景。
Objective To study the process of β-cyclodextrin （β-CD） inclusion techniques for volatile components in Qingnaoxingshen patch. Methods Inclusion techniques were selected by screening on uniform-design method, the content was identified by GC. Casting method was used to prepare into path. Results The study of a key process technology was completed. The optimal technical conditions were as follows., the ratio of β-CD and drug was 5 ： 1, temperature was 80 ℃, time was 60 min. Preparation of a new type of gel-matrix controlled-release type of patches was estimated. Conclusion This method is scientific and it may have a prosperous future.
出处
《中国中医药信息杂志》
CAS
CSCD
2010年第11期50-52,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
黑龙江省教育厅科学技术研究项目(11531357)
黑龙江中医药大学科研基金(200716)
黑龙江中医药大学大学生科技创新基金(99940)
关键词
清脑醒神贴
包合工艺
β-环糊精:均匀设计
Qingnaoxingshen patch
inclusion process
β-cyclodextrin
uniform-design
