冠心病患者血浆谷胱甘肽抗氧化系统的改变及其临床意义

The Changes and Its Clinical Significance of Glutathione Redox-state in Patients with Coronary Heart Disease

目的观察冠心病(CHD)患者血浆谷胱甘肽抗氧化系统的改变及其临床意义。方法选取我院心内科收治的30例无器质性心脏病、心功能正常的室上性心动过速患者(对照组),28例CHD高危患者(CHD高危组),以及60例CHD患者(CHD组)。测定并比较3组患者血浆还原型谷胱甘肽(GSH)、氧化型谷胱甘肽(GSSG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平。结果 CHD高危组、CHD组患者血浆GSH水平〔分别为(5.94±0.72)μmol/L和(5.62±0.74)μmol/L〕较对照组〔(6.51±0.91)μmol/L〕显著下降,GSSG水平〔(1.10±0.06)μmol/L和(1.14±0.06)μmol/L〕则较对照组〔(1.02±0.03)μmol/L〕显著升高,差异有统计学意义(P<0.05)。结论 CHD及CHD高危患者血浆GSH水平下降,GSSG水平升高,表明动脉粥样硬化时机体的抗氧化作用减弱,存在氧化应激,提示改善机体的氧化还原状态有可能减慢或阻止动脉粥样硬化的发生与发展。

Objective To study the changes and its clinical significance of glutathione redox-state in patients with coronary heart disease（CHD）.Methods 118 hospitalized patients were divided into 3 groups：control group（n=30）,CHD high-risk group（n=28） and CHD group（n=60）.The concentrations of reduced glutathione hormone（GSH） and oxidized glutathione（GSSG） and high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C） were measured.Results The concentration of GSH was significantly lower in CHD high-risk group and CHD group compared with control group（P0.05）,and the concentration of GSSG in CHD high-risk group and CHD group was significantly higher compared with control group（P0.05）.Conclusion The concentration of GSH decreased,and the concentration of GSSG increased in CHD patients and CHD high-risk patients,which shows that body＇s antioxidant capacity decreases and the oxidative stress exists in atherosclerosis.Improving this situation may decelerate or prevent the formation and progress of atherosclerosis.