老年高血压患者体内哇巴因水平与动脉弹性的相关性研究

Relationship between Ouabain Level and Artery Elasticity in Aged Patients with Hypertension

目的探讨老年高血压患者体内哇巴因水平与动脉弹性的相关性。方法入选86例老年高血压患者,检测其体内内源性哇巴因水平,通过检测脉压指数(PPI)、踝臂指数(ABI)、踝动脉-肱动脉脉搏波传导速度(baP-WV)、颈动脉内膜中层厚度(IMT)反映动脉弹性,并观察其与哇巴因之间的相关性。结果老年高血压患者体内内源性哇巴因水平与PPI及baPWV呈正相关(r值分别为0.676和0.618,P<0.05),与ABI呈负相关(r=-0.552,P<0.05)。不同性别、吸烟与不吸烟、有糖尿病和无糖尿病的老年高血压患者体内哇巴因水平间比较,差异均无统计学意义(P>0.05)。结论老年高血压患者体内哇巴因水平增高与动脉弹性减低呈正相关,性别、是否吸烟及是否患糖尿病与哇巴因水平无关。

Objective To investigate the relationship between ouabain level and artery elasticity in aged patients with hypertension.Methods The endogenous ouabain level was determined in enrolled 86 aged patients with hypertension.Arterial elasticity was reflected by detecting pulse pressure index（PPI）,ankle-brachial index（ABI）,ankle arteries-brachial artery pulse wave velocity（baPWV） and carotid artery intima-media thickness（IMT）,and its relationship to ouabain was observed.Results Endogenous ouabain was positively correlated with PPI（r=0.676,P〈0.05） and baPWV（r=0.618,P〈0.05）,negatively with ABI（r=-0.552,P〈0.05） in aged patients with hypertension.Conclusion In aged patients with hypertension,increase of ouabain level is positively correlated with decrease of artery elasticity,but not correlated with gender,smoking or having diabetes or not.