有机磷中毒并发呼吸衰竭的多因素临床分析

Multi-factor clinical analyses in acute Organophosphate Poisoning with respiratory failure

目的分析探讨有机磷中毒合并呼吸衰竭的临床特点、发生规律及危险因素。方法根据是否合并呼吸衰竭将有机磷中毒患者分为呼衰组及对照组,分析比较两组临床资料及实验室检查结果。结果经比较两组患者在APACHEⅡ评分、ACHE活力、CK、开始洗胃时间、肌颤持续时间、胆碱酯酶活力恢复时间及死亡率方面有显著性差异(P<0.05)。结论有机磷中毒患者易并发呼吸衰竭,其中洗胃时间延迟、胆碱酯酶活力低下、胆碱酯酶活力恢复延迟及APACHEⅡ评分、肌酸激酶水平可能是预测是否发生呼吸衰竭的相关危险因素。

Objective To analyze clinical characteristics and risk factorsin acute Organophosphate Poisoning with respiratory failure.Methods According to whether complicated respiratory failure,Organophosphate poisoning patients were divided into control group and failure group.Clinical data and laboratory tests were compared between two groups.Results Two groups have significant difference（P 0.05） in followed aspects as APACHEⅡ score,AchE,CK,gastric lavage time,fibrillation duration,AchE recovery time and mortality.Conclusion Organophos poisoning patients complicated respiratory failure have such characteristics including to gastric lavage time and AchE recovery time delay、low AchE activity、high APACHEⅡscore and creatine kinase level.