IL-8在AECOPD的表达及糖皮质激素对其影响的研究被引量：14

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摘要目的白细胞介素-8(IL-8)参与慢性阻塞性肺疾病(COPD)的发病机制,本研究进一步探讨IL-8在COPD急性发作期(AECOPD)的表达及糖皮质激素在COPD治疗中的价值。方法选择AECOPD患者60例及健康对照组20例,测定血清IL-8水平;然后将60例COPD患者随机分为两组,一组常规抗炎、对症治疗,另一组在常规治疗基础上加用糖皮质激素治疗,10天后分别抽血测定IL-8水平,观察两组COPD治疗前后IL-8的变化,并与健康对照组比较。结果 AECOPD患者IL-8水平明显高于健康对照组(P<0.05);经治疗,两组COPD患者血清IL-8水平均下降,但仍高于健康对照组,其中激素治疗组IL-8水平下降较常规治疗组更为明显。结论 IL-8参与了COPD气道炎症反应,并在炎症瀑布效应中起主要作用;糖皮质激素能降低AE-COPDIL-8水平,减轻气道炎症反应,更快的改善临床症状。

作者赵华关键许西琳

机构地区石河子大学医学院第一附属医院呼吸内科

出处《临床肺科杂志》 2010年第12期1793-1794,共2页 Journal of Clinical Pulmonary Medicine

关键词 IL-8水平 AECOPD 糖皮质激素 COPD患者 COPD急性发作期气道炎症反应健康对照组慢性阻塞性肺疾病

分类号 R563.9 [医药卫生—呼吸系统]

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参考文献5

1慢性阻塞性肺疾病诊治指南(2007年修订版)[J].中华结核和呼吸杂志,2007,30(1):8-17. 被引量：8234
2侯静静,朱蕾.白介素-8与慢性阻塞性肺疾病[J].国外医学（呼吸系统分册）,2005,25(6):427-429. 被引量：44
3De Boer WI,Sont J K,Van Schadewijk A,et al.Monocyte chemoattractant protein 1,interleukin-8 and chronic airways inflammation in COPD[J].J Pathol,2000,190:619-626.
4董平,孔令敏,陈文靖,赛立夏,康炳玲.COPD急性发作期白介素-8、肿瘤坏死因子-α的表达与预后分析[J].中国厂矿医学,2002,15(2):99-100. 被引量：12
5Barnes PJ.Potential novel therapies for chronic obst ructive pulmonary disease[J].Novartis Found Symp,2001,234:255-267;discussion 267-272.

二级参考文献18

1有创-无创序贯机械通气多中心研究协作组.以肺部感染控制窗为切换点行有创与无创序贯机械通气治疗慢性阻塞性肺疾病所致严重呼吸衰竭的随机对照研究[J].中华结核和呼吸杂志,2006,29(1):14-18. 被引量：279
2Griffhs CEM, Voor hees JJ, Nickoloff BJ. Characterization of intercellular adhesion molecular - 1 and HLA- DR expression in normal and inflamed skin: modulation by recombinat interferon and tumor necrosid factor.J Acad Dermatol, 1989,20:1097.
3Ulich TR, Yin S, Guo K, et al. Intracheal injection of endotoxin and cytokine: interleukin - 6 and transforming growth factor beta inhibit acute inflammation. Am J Pathol, 1991,138:1097.
4Hasday JD, McCrea SS, et al. Dysredulation of airway cytokine expression in chronic obstctive pulmonary disease and asthma. Am J Respin Care Med, 1994,150(supple):54.
5Schols AM, Buurman WA, Staal - van den Brekel AJ, et al. Evidence for a relation between metabolic derangements and increased levels of inflammatory mediatorsin a subgroup of patients wish chronic obstructive pulmonary disease. Thorax,1996,51:819.
6Schleimer RP,Benenati SV,Friedman B,et al. Do eytokines play arole in leukocyte recruitment and activation in the lungs? Am Respir Dis, 1991,143: 1169.
7Nakamura H, Yoshimura K, McElvaney NG, et al. Neutrophil elastase in respiratory epithelial lining fluid if in lividuais with cystic fibrosis induces interlenkin - 8 gene expression in a human bronchial epitheial cell line. J Clin Invest, 1992,89:1478.
8GOLD Executive Committee[DB/OL].Guidelines:Global Strategy for Diagnosis,Management,and Prevention of COPD,November 2006[2006-11-18].http://www.goldcopd.com/Guidelineitem.asp? l1 =2-12 = 1&intId =989.
9Celli BR,MacNee W,Committee members.Standard for the diagnosis and treatment of patients with COPD:a summary of the ATS/ERS position paper.Eur Respir J,2004,23:932-946.
10Celli BR,Cote CG,Marin JM,ct al.The body mass index,airflow obstruction,dyspnea and exercise capacity index in chronic obstructive pulmonary disease.N Engl J Med,2004,350:1005-1012.