甲硝唑根管消毒控释系统的临床应用研究

The clinical study of controlled release delivery guttapercha point containing metronidazole

目的：观察甲硝唑根管消毒控释系统（ＣＲＤＧＭ）治疗根尖周病的疗效及体内抑菌情况。方法：对封甲醛甲酚两次以上仍有症状的患牙改封ＣＲＤＧＭ；对急性期患牙根管内封ＣＲＤＧＭ，以口服甲硝唑对照；根管治疗一次法分ＣＲＤＧＭ及牙胶尖根充两组；将ＣＲＤＧＭ封入单根管患牙内，治疗前后根管内取样作厌氧培养，以甲醛甲酚对照。结果：９３．３％的患牙根尖症状消失；两组在控制急性症状上无差异；ＣＲＤＧＭ根充组术后不良反应及急性症状发生率明显低于牙胶尖组；随着时间延长ＣＲＤＧＭ组根管内厌氧菌检出率明显低于甲醛甲酚组。结论：ＣＲＤＧＭ作根管消毒剂及根充材料有良好的抗感染能力。

Objective: To study the effects of controlled release delivery system containing metronidazole(CRDGM) in the treatment of apical periodontal disease and the antibacterial potential of CRDGM. Methods: CRDGM was used in the cases with acute and chronic apical periodontitis. The clinical results were observed by regular followup. The in vivo antibacteria action of CRDGM was investigated with an antibiotic susceptibility test. Results: The apical symptoms disappeared in 93.3% of the treated teeth, and the accessory symptoms reduced when CRDGM was used as root canal filling material. The antibacterial effect of CRDGM was superior to that of formocresol. Conclusion: CRDGM, with strong antibacterial potential, can be used as root canal disinfection agent or filling material, and may be used to treat apical periodontitis instead of oral medication under certanin conditions.