地塞米松短期冲击治疗急慢性病毒性肝炎高胆红素血症30例临床观察

Dexamethasone Short-term Shock Therapy for Acute or Chronic Hepatitis Associated with Hyperbilirubinemia:An Observation of 30 Cases

目的:探讨地塞米松在急慢性肝炎伴高胆红素血症治疗过程中的疗效。方法:将我科在2007—2010年收治的60例急慢性肝炎患者随机分为治疗组和对照组,对照组采用常规的治疗急慢性肝炎的方法,治疗组在常规保肝退黄的基础上加用地塞米松短期冲击治疗。在治疗前及治疗后的检测患者肝功能及总胆红素的变化情况并进行疗效的评价。结果:治疗组的TB、ALB在出院时与入院时相比有显著的统计学差异(P<0.05),出院时治疗组与对照组的TB水平相比具有统计学上的差异(P<0.05),治疗组的总体有效率为93.33%,明显高于对照组的73.33%,两组相比有统计学差异(P<0.05),治疗组的疗效优于对照组。结论:地塞米松在急慢性肝炎的治疗过程中使用效果显著,安全性较高。

OBJECTIVE：To observe the therapeutic efficacy of dexamethasone on acute or chronic hepatitis associated with hyperbilirubinemia.METHODS：60 patients with acute or chronic hepatitis treated in our hospital from 2007 to 2010 were randomly assigned to receive dexamethasone（short term shock therapy） plus routine therapy（treatment group） or routine therapy alone（control group）.The liver function and total bilirubin were tested before and after treatment,and the therapeutic efficacy in the two groups was evaluated.RESULTS：There were significant differences in plasma levels of TB（total bilirubin） and ALB（albumin） for the treatment group at the time of discharge as compared with those at the time of admission（P 〈 0.05）,and there were also significant differences between the treatment group and the control group regarding plasma TB level at the time of discharge（P 〈 0.05）.There were significant differences between the treatment group and the control group in total effective rate（93.33% vs.73.33%,P 〈 0.05）.The therapeutic efficacy in the treatment group was much better than in the control group.CONCLUSION：Dexamethasone has remarkable therapeutic efficacy and good safety in the treatment of acute or chronic hepatitis associated with hyperbilirubinemia.