113例抗病原微生物药致不良反应报告分析

Adverse Drug Reactions Induced by Anti-microbial Drugs:Analysis of 113 Cases

目的:分析遂宁市中心医院抗病原微生物药致不良反应(ADR)的发生规律及特点,推动临床合理用药。方法:对我院2008年1月—2010年1月上报的113例抗病原微生物药引起的不良反应报告进行统计分析。结果:在>60岁年龄段发生的ADR构成比高(51例,占54.13%);导致ADR的10种抗病原微生物药中β-内酰胺类发生率最高,其中,头孢菌素类及青霉素类药物构成比较高,分别为31.86%和28.32%;ADR的临床表现主要以皮肤及附件损害(56例,49.56%)、消化系统损害(13例,11.51%)多见。结论:建议在临床应用中加强抗病原微生物药ADR监测,最大限度地减少ADR的发生,促进临床合理用药。

OBJECTIVE：To investigate the regular pattern and features of adverse drug reactions（ADRs） induced by anti-microbial drugs in our hospital so as to improve rational clinical drug use.METHODS：A total of 113 ADR cases reported by our hospital from Jan.2008 to Jan.2010 were analyzed statistically.RESULTS：Of the total 113 ADR cases reported,51 cases（54.13%） were elder patients aged over 60 years old.Of the 10 anti-microbial drugs that induced ADRs,leading the list were β-lactams in terms of ADR incidence,followed by cephalosporins（31.86%） and penicillins（28.32%）.The ADR manifested predominantly as lesions of skin and its appendage in 56 cases（49.56%）,followed by lesions of digestive system in 13 cases（11.51%）.CONCLUSION：It is advisable to tighten ADR monitoring of anti-microbial drugs to minimize ADR incidence to an utmost and promote clinical rational drug use.