粒-巨噬细胞集落刺激因子可作为卵巢恶性肿瘤标志物

Granulocytemacrophage colonystimulating factor as a tumor marker for ovarian cance

目的：检测造血细胞肿瘤与非造血细胞肿瘤粒－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）的表达。方法：测定３０例卵巢恶性肿瘤，２０例卵巢良性肿瘤和４例正常卵巢组织的ＧＭ－ＣＳＦ及ＣＡ－１２５、ＣＥＡ表达情况。结果：ＧＭ－ＣＳＦ只在卵巢恶性肿瘤组织中表达，２０例卵巢良性肿瘤中无一例表达，４例正常卵巢组织对照呈阴性反应。ＣＡ－１２５在卵巢良性及恶性肿瘤组织中均有表达，ＣＥＡ在卵巢恶性肿瘤组织中仅有低表达。９０％卵巢恶性肿瘤组织表达ＧＭ－ＣＳＦ，７７％卵巢恶性肿瘤组织表达ＣＡ－１２５，３５％卵巢良性肿瘤组织表达ＣＡ－１２５，只有１６％卵巢恶性肿瘤组织表达ＣＥＡ。ＧＭ－ＣＳＦ与ＣＡ－１２５结合阳性率可达９７％。结论：ＧＭ－ＣＳＦ可作为卵巢恶性肿瘤标志物。

Objective: To detect granulocytemacrophage colonystimulating factor (GMCSF)in hematopoietic and nonhematopoietic tumor cells. Methods: GMCSF was examined in 30 cases of malignant ovarian tumors, 20 of benign ovarian tumors and 4 with normal ovarian tissues as control. At the same time, CA125 and CEA were also examined. Results: 90% malignant ovarian tumors expressed GMCSF, while benign ovarian tumors did not express GMCSF. CA125 was expressed in both malignant(77%) and benign ovarian tumors(35%). CEA was expressed only in 16% of ovarian cancers. Positive percentage with GMCSF combining with CA125 was 97%. Conclusion: GMCSF may serve as a tumor marker for ovarian cancer.