Relationship between serum copper and protein thiols in hyperlipidemic patients

Relationship between serum copper and protein thiols in hyperlipidemic patients

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摘要 Objective:To measure serum copper and protein thiols along with lipid profile in hyperlipidemic patients and to establish the relationship between serum copper,protein thiols and lipid profile parameters.Methods: The study group consisted of 26 newly diagnosed hyperlipidemic patients not associated with any other systemic diseases and 26 age and sex matched healthy controls.Fasting lipid profile was done by enzymatic method using automated analyzer.Serum copper and protein thiols were measured spectrophotometrically.Results: Serum copper and protein-SH levels were significantly decreased in cases(P<0.01,P<0.01) compared to controls.Serum copper correlated positively with protein thiols(r=0.800,P<0.01) and negatively with LDL cholesterol(r=-0.351 P<0.05).Conclusion: Serum copper and protein thiols were decreased in hyperlipidemia and they correlated positively indicating protective role of copper in preventing homocysteinylation of protein and hence in preventing atherosclerosis. Objective：To measure serum copper and protein thiols along with lipid profile in hyperlipidemic patients and to establish the relationship between serum copper,protein thiols and lipid profile parameters.Methods： The study group consisted of 26 newly diagnosed hyperlipidemic patients not associated with any other systemic diseases and 26 age and sex matched healthy controls.Fasting lipid profile was done by enzymatic method using automated analyzer.Serum copper and protein thiols were measured spectrophotometrically.Results： Serum copper and protein–SH levels were significantly decreased in cases（P0.01,P0.01） compared to controls.Serum copper correlated positively with protein thiols（r=0.800,P0.01） and negatively with LDL cholesterol（r=-0.351 P0.05）.Conclusion： Serum copper and protein thiols were decreased in hyperlipidemia and they correlated positively indicating protective role of copper in preventing homocysteinylation of protein and hence in preventing atherosclerosis.

作者 Jeevan K Shetty Suresh Babu Sudeshna Tripathy Mungli Prakash

机构地区 Department of Biochemistry Deartment of Biochemistry Indian institute of Science Bangalore Department of Biochemistry and Genetics

出处《海南医学院学报》 CAS 2010年第10期1266-1268,共3页 Journal of Hainan Medical University

关键词糖尿病高血脂高血糖临床 Hyperlipidemia Serum Copper Protein thiols Low density lipoprotein

分类号 R587.1 [医药卫生—内分泌]

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1Mungli Prakash,Jeevan K Shetty,Sudeshna Tripathy,Pannuri Vikram,Manish Verma.Serum paraoxonase activity and protein thiols in patients with hyperlipidemia[J].海南医学院学报,2009,15(2):111-113.

海南医学院学报

2010年第10期

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Relationship between serum copper and protein thiols in hyperlipidemic patients

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