血清肿瘤标记物联合检测在预测肝癌复发患者中的诊断价值

Diagnosis value of combined detection of serum tumor markers in predicting recurrence in patients with liver cancer

目的:探讨联合检测血清中的α-L-岩藻糖苷酶(AFU)、甲胎蛋白(AFP)在预测肝癌术后复发的价值。方法:分别检测3组AFU、AFP,AFU检测均采用比色速率法测定,设定AFU>40 U/L、GPDA>41 U/L为阳性界定值。AFP检测采用微粒子酶免法,设定AFP>13.6μg/L为阳性界定值。结果:AFU、AFP水平A组与B组及正常对照组比较差异有统计学意义(P<0.001);AFU、AFP水平B组较正常对照组高,但差异无统计学意义(P>0.05);AFU、AFP水平A组肝癌复发前、后比较差异有统计学意义(P<0.001);敏感性、准确性AFU+AFP与AFU、AFP比较差异有统计学意义(P<0.001),AFU与AFP比较差异无统计学意义(P>0.05);特异性AFU+AFP、AFU、AFP两两比较差异无统计学意义(P>0.05)。结论:联合检测血清中AFU、AFP水平可显著提高肝癌术后复发的诊断率,可作为预测肝癌术后复发的检测指标。

Objective： To explore diagnosis value of the combined detection of serum AFU,AFP in predicting postoperative recurrence of hepatocellular carcinoma.Methods： The serum AFU,AFP levels were detected in three groups,AFU detection rate was used by colorimetric determination,respectively,set the AFU40 U / L,GPDA41 U / L defined as positive values.AFP was detected by microparticle enzyme immunoassay,set AFP 13.6μg / L defined as positive values.Results： AFU,AFP levels of group A,group B and normal control group were significantly different（P0.001）;AFU,AFP levels of group B were higher than that of the normal control group,but no significant difference（P0.05）.AFU,AFP levels of group A before and after HCC recurrence were significant difference（P0.001）.Sensitivity,accuracy of AFU ＋ AFP and AFU,AFP were significantly different when compared（P0.001）;AFU and AFP were no significant difference（P0.05）;specificity of AFU ＋ AFP,AFU,AFP were no significant differences（P0.05）.Conclusion： The combined detection of serum AFU,AFP levels could significantly improve the diagnostic rate of liver cancer recurrence,may be as a predictor of postoperative recurrence of liver cancer detection indicators.