缬沙坦联合吲哒帕胺治疗老年高血压81例临床效果观察

Effect of combined therapy with valsartan and indapamide on senile hypertension

目的:探讨缬沙坦联合吲哒帕胺治疗老年高血压病的临床效果。方法:选择我院2008年1月～2010年1月老年高血压患者81例,随机分为观察组41例和对照组40例。所有患者均停用其他降压药物1周以上。对照组患者给予缬沙坦,每天80 mg;观察组在对照组用药基础上,给予吲达帕胺缓释片,每次1.25 mg,每天1次。两组患者共治疗4周。结果:观察组治疗后舒张压、收缩压分别和对照组治疗后比较,差异有统计学意义(P<0.05);两组患者总有效率比较,差异有统计学意义(P<0.05)。结论:缬沙坦联合吲哒帕胺治疗老年高血压病临床效果显著,值得借鉴。

Objective： To explore the effect of combined therapy with valsartan and indapamide on senile hypertension.Methods： A total of 81 cases with senile hypertension admitted from Jan.2008 to Jan.2010 were randomly divided into observation group（41 cases） and control group（40 cases）.All patients had drug withdrawal for more than 1 week.Patients in control group were treated with valsartan 80 mg per day for 4 weeks,and observation group with indapamide 1.25 mg per day for 4 weeks.Results： Diastolic and systolic pressure and total efficiency in observation group were significantly different from those in control group（P0.05）.Conclusions： Combined therapy with valsartan and indapamide is effective on treatment of senile hypertension.