新疆维吾尔族妇女宫颈上皮内瘤变及宫颈鳞癌组织中VEGF-C的表达及意义

The expressions of VEGF-C in cervical intraepithelial neoplasia and cervical squamous carcinoma and its significance in women of Uygur nationality in Xinjiang

目的:探讨新疆维吾尔族妇女宫颈上皮内瘤样病变(CIN)及宫颈癌组织中VEGF-C的表达及其与临床病理特征的关系。方法:应用免疫组化方法检测慢性宫颈炎22例、CIN24例及宫颈癌活检与手术切除43例标本中VEGF-C的表达,并与临床病理参数进行比较分析。结果:慢性宫颈炎、CIN及宫颈癌组中VEGF-C阳性表达率分别为9.1%、87.5%、100.0%,差异有统计学意义(P<0.01);VEGF-C在临床Ⅰ～Ⅱ期和Ⅲ～Ⅳ期宫颈癌组中强阳性表达率分别是44.1%、88.9%,差异有统计学意义(P<0.05);在组织分化1～2级和3级的宫颈癌患者中强阳性表达率分别是51.6%和58.3%,差异无统计学意义(P>0.05);在肿瘤直径≤4cm的宫颈癌组织中的强阳性表达率是40.0%,>4cm的宫颈癌组织中的强阳性表达率是72.2%,差异有统计学意义(P<0.05);CT显示有淋巴结肿大的宫颈癌组织中VEGF-C的阳性表达率是65.5%,高于无淋巴结肿大的宫颈癌组织中的阳性表达率28.6%,差异有统计学意义(P<0.05);早期手术的24例宫颈癌标本中没有淋巴浸润及有淋巴浸润VEGF-C强阳性表达率分别是55.6%和50.0%,差异无统计学意义(P>0.05);在肿瘤浸润宫颈浅肌层与深肌层VEGF-C强阳性表达率分别是50.0%和60.0%,差异无统计学意义(P>0.05)。结论:新疆维吾尔族妇女宫颈癌组织中VEGF-C阳性的表达与临床分期、肿瘤的大小及CT显示淋巴结肿大呈显著相关,与组织学分化、肿瘤浸润的程度及淋巴结的浸润无关。

Objective：To explore the expressions of vascular endothelial growth factor-C（VEGF-C） in cervical intraepithelial neoplasia（CIN） and cervical squamous carcinoma and its relationship with clinicopathological characteristics in women of Uygur nationality in Xinjiang.Methods：Immunohistochemical method was used to detect the expression levels of VEGF-C in 22 samples of chronic cervicitis,24 samples of CIN and 43 samples of cervical squamous carcinoma biopsy and exairesis,and the clinicopathological parameters were compared and analyzed.Results：The positive expression rates of VEGF-C in chronic cervicitis,CIN and cervical carcinoma were 9.1%,87.5% and 100.0%,respectively,there was significant difference（P0.05）.The strong positive expression rates of VEGF-C in cervical carcinoma of stage Ⅰ-Ⅱ and stage Ⅲ were 44.1% and 88.9%,respectively,there was significant difference（P0.05）;the strong positive expression rates of VEGF-C in cervical carcinoma of grade 1～2 and grade 3 were 51.6% and 58.3%,respectively,there was no significant difference（P0.05）;the strong positive expression rates of VEGF-C in cervical carcinoma with diameter≤4 cm and diameter4 cm were 40.0% and 72.2%,respectively,there was significant difference（P0.05）;the positive expression rate of VEGF-C in cervical carcinoma with lymphadenectasis was 65.5%,which was significantly higher than that without lymphadenectasis（28.6%）（P0.05）.Among 24 cases with cervical squamous carcinoma receiving early operation,the strong positive expression rates of VEGF-C in cervical carcinoma without lymphatic metastasis and with lymphatic metastasis were 55.6% and 50.0%,respectively,there was no significant difference（P0.05）;the strong positive expression rates of VEGF-C in cervical carcinoma with superficial muscular layer invasion and deep muscular layer invasion were 50.0% and 60.0%,respectively,there was no significant difference（P0.05）.Conclusion：The positive expression of VEGF-C in cervical carcinoma is related to clinical stages,tumor sizes and lymphadenectasis significantly in women of Uygur nationality in Xinjiang,but it is independent of histological differentiation,the depth of tumor invasion and lymphatic metastasis.