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苯乙酸钠诱导人白血病细胞HL60凋亡及其机制

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摘要 目的探讨苯乙酸钠(NaPA)诱导人粒单核系白血病细胞株HL60细胞凋亡机制及对细胞周期各时相的影响。方法检测不同浓度NaPA对HL60细胞存活率、细胞周期、上清血小板衍化生长因子β(PDGF-β)分泌水平、凋亡相关蛋白Bc l-2和Bax表达的影响。结果不同浓度NaPA作用后,HL60细胞存活率降低,PDGF-β的分泌量减少,HL60细胞阻滞在G0/G1期,Bcl-2蛋白水平降低,Bax蛋白水平上升。结论推测调节PDGF-β分泌水平及Bcl-2和Bax的表达为NaPA诱导人白血病细胞HL60凋亡的机制之一。
作者 李旸 张嵘 胡荣 潘梦瑶 刘卓刚
机构地区 中国医科大学附属盛京医院
出处 《山东医药》 CAS 北大核心 2010年第40期60-61,共2页 Shandong Medical Journal
关键词 苯乙酸钠 白血病 HL60 细胞凋亡
分类号 R733.7 [医药卫生—肿瘤]
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参考文献6

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山东医药
2010年 第40期

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