摘要
目的建立非布司他溶出度的测定方法。方法依照《中国药典》2005年版二部附录溶出度项下第二法,磷酸盐缓冲液(pH6.8)为溶出介质,转速为50r/min,紫外可见分光光度法测定,检测波长为315nm。结果在1.813～18.131g/mL范围内(r=1.000),浓度与吸光度呈良好的线性关系,平均回收率为99.93%,RSD为0.59%(n=9)。结论该法操作简便、准确可靠,可作为非布司他的质量控制方法。
Objective To establish the dissolution determination of Febuxostat Tablets with UV spectroph otography.Methods According to the 2005 editional appendix of The Pharmacopoeia of the PRC,phosphate buffer with pH=6.8 was the dissolution medium,and the scan wavelength was 315nm.Results The absorption was good linear in the concentraion range of 1.813～18.131 g/mL （r=1.000）.The average recovery was 99.93%,RSD=0.59%（n=9）.Conclusion The method is good,simple and accurate,which can be used as quality control method.
出处
《医学研究与教育》
CAS
2010年第5期8-10,共3页
Medical Research and Education
基金
国家自然科学基金资助项目(200511140231)
