普通干扰素联合利巴韦林治疗ALT正常的慢性丙型肝炎的临床研究

Treatment for chronic hepatitis C patients with normal serum alanine aminotransferase by normal IFN and ribavirin

目的评价普通干扰素联合利巴韦林治疗ALT正常的慢性丙型肝炎的临床疗效。方法使用普通干扰素α-1b联合利巴韦林治疗33例ALT正常和31例ALT升高的慢性丙型肝炎患者。分别于治疗4、12、48周及治疗结束后24周评价疗效。结果 ALT正常组和ALT升高组RVR、EVR、ETVR、SVR应答情况分别为19(57.6%)、21(63.6%)、24(72.7%)、21(63.6%)和18(60.0%)、20(66.7%)、25(83.3%)、23(76.6%),所有疗效指标两组对比均无显著差异。两组患者肝功能变化和不良反应发生情况无明显差异。结论普通干扰素联合利巴韦林治疗ALT正常的慢性丙型肝炎一样具有较好的临床疗效。

Objective To evaluate the clinical effects of normal interferon and ribavirin treatment on chronic hepatitis C patients with normal serum alanine aminotransferase（ALT）. Methods 33 chronic hepatitis C patients with normal ALT and 31 patients with increased ALT were treated with normal interferon and ribavirin. Curative effect were evaluated at the 4, 12 and 48 weeks during the treatment. Following up studies were conducted at the 24th week after the treatment. Results The response rate of the normal ALT and increased ALT group about RVR, EVR, ETVR, SVR were respectively 19（57.6% ）, 21 （63.6%） ,24 （72.7%） ,21 （63.6%） and 18 （ 60.0% ）, 20 （ 66.7 % ）, 25 （ 83.3 % ） ,23 （ 76.6% ） o All indexes had no statistically significant difference between the normal ALT and increased ALT group. The indexes of liver function and adverse reaction had no statistically significant difference between the two groups. Conclusion Combination of normal interferon and ribavirin may be used for the treatment of ehronie hepatitis C patients with normal serum alanine aminotransferase.