2006年我国十省市抑郁障碍患者药物治疗现况调查

The second cross-sectioned study on antidepressants patterns of depression in China

目的 调查2006年我国10省市抑郁障碍患者药物治疗现况.方法 按照经济发展水平进行分层和方便取样方法,选择10省市41所精神疾病专科医院或综合医院精神科的1354例抑郁障碍门诊和住院患者,于2006年5月22-28日使用自制修订的调查问卷进行调查.结果 （1）1354例患者中,门诊患者921例（68.0%）,住院患者433例（32.0%）;男473例（34.9%）,女873例（64.5%）,缺失8例（0.6%）.（2）1281例（94.6%）患者接受抗抑郁药治疗,其中798例（62.3%）患者使用选择性5-HT再摄取抑制剂（SSRIs）治疗,以单一治疗为主（792例,99.2%）,使用频率前7位的药物依次为：帕罗西汀312例（24.4%）,氟西汀260例（20.3%）,文拉法辛250例（19.5%）,西酞普兰141例（11.0%）,舍曲林81例（6.3%）、米氮平53例（4.1%）;219例（17.1%）患者使用三环类药物治疗.（3）590例（43.6%）患者使用苯二氮革类药物治疗,281例（20.8%）患者使用抗精神病药,88例（6.5%）患者使用心境稳定剂;住院患者合并苯二氮革类药物的比例显著高于门诊患者（P＜0.05）,急性治疗期合并苯二氮革类药物的比例显著高于稳定治疗期（P＜0.01）.结论 新型抗抑郁药已经成为我国治疗抑郁障碍的主要药物,反映出目前抗抑郁药的发展趋势及抑郁障碍治疗理念的更新.

Objective To uncover the antidepressants drug use patterns for treating depression in China in 2006, and the developing tendency for past 4 years. Methods Based on economic levels in different provinces and the convenient sampling, totally 41 hospitals from 10 provinces and cities were selected out. The investigation was conducted during May 22th -28th, 2006, using the revised self-made questionnaire. Results The total number of the sample was 1354, including outpatients （68.0% ） and with pharmacotherapy, and the antidepressants most frequently prescribed were paroxetine （24.4% of the 1354 patients）, fluoxetine （20.3% ）, venlafaxine （19.5%）, citalopram （11.0%）, sertraline （6.3% ）,and mirtazapine （4.1% ）, while 219 patients （ 17.1% ） were treated with TCAs. 62.3% of patients were treated with SSRIs, and most of them administered monotherapy. The frequency of benzodiazepine,antipsychotics and mood stabilizers used were 43.6%, 20.8% and 6.5%, respectively. Comparing to the outpatients, the frequency to use the benzodiazepine and antipsychotics for the inpatients was higher （P 〈 0.05）. And more patients in acute phase used benzodiazepine than those who were in maintenance phase （P 〈 0.01 ）. Conclusion Novel antidepressants are the mainstream to treat patients with depression in China, the tendency of antidepressants prescription pattern matches the development of treatment outcome and treatment techniques for depression.