摘要
5-脂氧酶(5-LO)是重要炎症介质白三烯类(LTs)合成的关键性限速酶。缺氧缺糖(OGD)损伤可诱导5-LO激活,发生核膜移位和生成LTs,OGD激活5-LO与ROS-P38MAPK信号通路有关。
5-Lipoxygenase （5-LO） is a key enzyme metabolizing arachidonic acid to produce leukotrienes （LTs）. Oxygenglucose deprivation （OGD）-induced ischemic-like injury induces 5-LO activation, which is mediated by oxidative stress through activating the P38 mitogen-activated protein kinase pathway.
出处
《健康研究》
CAS
2010年第5期387-389,393,共4页
Health Research
基金
浙江省自然科学基金资助项目(Y204210)
杭州市科技计划项目(20080333B21)
关键词
脑缺血
5-脂氧酶
缺氧缺糖
白三烯类
炎症
Cerebral ischemia
5-1ipoxygenase
Oxygen-glucose deprivation
Leukotrienes
Inflammation
