微波辐射合成阿司匹林的研究

Microwave-Induced Synthesis of Aspirin on Different Catalysts

以水杨酸和乙酸酐为原料,选用不同催化剂,用微波法快速合成阿司匹林.通过实验考察了原料用量比、不同催化剂、微波辐射功率、辐射时间等因素对产率的影响,得到了最佳合成工艺条件:水杨酸和乙酸酐量的比为1∶1.5,微波功率为550 W,用乙酸钾作催化剂,辐射时间5 min时,纯化后产物产率高达81.46%.

Aspirin was synthesized through O-acylating reaction from salicylic acid and acetic anhydride by microwave radiation with sodium acetate as catalyst. Several factors influencing on the reaction yield such as the kind of catalysts,the ratio of salicylic acid to acetic anhydride,the power of microwave radiation, the time of microwave radiation and thc optimum method was gained. The result indicates that microwave synthesis has many advantages including simplification in method, time saving, no pollution and good quality for the sample. The method is suitable for green chemical synthesis in industrial producing.