健康体检人群脉搏波传导速度现状调查

Pulse wave velocity in individuals undergoing physical examinations

目的 探讨动脉硬化早期无创检测技术及其主要指标在健康体检中的流行现状.方法 通过统一设计收集全国不同区域的27家体检中心的46824名健康体检者（男性24879名、女性21945名）动脉硬化无创检测数据资料及受试者相关基础信息,通过分析得到国人不同年龄段脉搏波传导速度（PWV）的常值范围、异常检出率,并分析PWV的主要影响因素.结果 不同性别体检人群PWV平均值及异常检出率随着年龄增长而增加,在60岁之前,男性PWV异常检出率明显高于女性（P〈0.05）,在60岁之后女性高于男性.PWV异常检出率风险分层结果,PWV〉1400 cm/s（轻度异常）、PWV〉1700 cm/s（中度异常）、PWV〉2000 cm/s（明显异常）的检出率分别为34.5%、7.5%和1.9%.相关结果分析,年龄和平均收缩压是影响PWV和ABI的主要因素（P〈0.05）.结论 动脉硬化早期无创检测技术及其主要指标PWV在健康体检与心血管病早期风险筛查中具有较好的应用价值.

Objective To explore the use of non-invasive technique for early detection of atherosclerosis in health checkups. Methods A total of 46 824 healthy normotensive volunteers, including 24 879 men and 21 945 women, from 27 physical examination centers were reviewed for their clinical data. Pulse wave velocity （PWV） by age was calculated,and related factors of PWV were analyzed. Results Reference range of PWV was increased with age. Detectable rate of abnormal PWV in men 〈 60 years was significantly higher than women （P〈0.05）. Detectable rate of PWV of 〉 1400 cm/s, 〉 1700 cm/s or 〉 2000 cm/s were 34. 5% ,7. 5% and 1.9% Respectively. Correlation analysis showed that PWV was closely related with age and mean systolic blood pressure （ P 〈 0. 05 ）. Conclusion Non-invasive technique for early detection of atherosclerosis and PWV should be useful in physical examinations and cardiovascular disease screening.