老年高血压患者同型半胱氨酸相关因素分析

The analysis of the related factors of homocysteine in elderly hypertensive patients

目的:探讨老年高血压患者同型半胱氨酸相关因素。方法:选择来我院体检和疗养的232名老年高血压患者(≥60岁),进行问卷调查、体格检查、血压检测、血生化、Hcy、叶酸、维生素B12检测。以Hcy为因变量,与性别、年龄、体重指数、伴随疾病(2型糖尿病、冠心病、脑卒中和慢性胃炎)、高血压病程、收缩压(SBP)、舒张压(DBP)、尿酸(UA)、空腹血糖(FPG)、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、叶酸、维生素B12等因素作简单相关分析及Logistic回归分析。结果:单因素分析显示:Hcy与年龄、UA、DBP呈正相关,与性别、叶酸、维生素B12呈负相关。Logistic回归分析显示:叶酸和UA为老年高血压患者Hcy的独立相关因素。结论:提高血清叶酸水平,或降低尿酸水平,可能是减少老年高血压患者血Hcy的重要途径。

Objective：To investigate the related factors of homocysteine in elderly hypertensive patients.Methods：Choose 232 elderly hypertensive patients who came to our hospital for medical examination or recuperation（≥ 60 years）,it is conducted a questionnaire survey,physical examination,blood pressure testing,blood biochemistry,Hcy,folic acid,vitamin B12 testing.It takes Hcy as the dependent variable,and makes simple related analysis and Logistic regression analysis of gender,age,body mass index,accompanying disease（type 2 diabetes,coronary heart disease,stroke and chronic gastritis）,hypertension,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,uric acid（UA）,fasting plasma glucose（FPG）,cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,folic acid,vitamin B12.Results： Univariate analysis shows that Hcy is positively correlated with age,UA,SBP;on the contrary,Hcy is negatively correlated with sex,folic acid,vitamin B12.Logistic regression analysis shows that the independent related factors of Hcy are folic acid and UA.Conclusions： It is concluded that an important way to reduce Hcy in elderly hypertensive patients is to improve serum folic acid levels or reduce uric acid levels.