蛋白酶激活受体-1在结肠癌组织中的表达及其临床意义

The Expression and Clinical Significance of Proteinase Activated Receptor-1(PAR-1) in Colon Cancer

目的:观察并探讨蛋白酶激活受体-1(proteinase activated receptor-1,PAR-1)在结肠癌组织中表达的临床意义。方法:用免疫组织化学方法检测65例结肠癌及其癌旁肠组织中PAR-1的表达情况。结果:PAR-1的表达在结肠癌组织中高于癌旁肠组织,随肌壁癌组织浸润度和淋巴结转移程度的提升而增高,均有显著差异(P<0.01);PAR-1的表达虽随着癌分化程度降低而增高,但无显著差异(P>0.05)。结论:PAR-1的表达与结肠癌发展及临床病理分期有关,可作为结肠癌临床预后指标之一。

Objective：To investigate the expression and clinical significance of proteinase activated receptor-1（PAR-1） in colon cancer.Methods： The expression of PAR-1 was studied by immunohistochemistry in 73 cases of colon cancer tissue and latero-cancer tissue.Results： The expression of PAR-1 in colon cancer tissue was significantly higher than that in latero-cancer tissue.The positive rates of PAR-1 were increased with the depth of wall invasion and lymphatic metastasis.All above had statistical significance（P0.05）.But the expression rates of PAR-1 were not related with the degree of differentiation（P0.05）Conclusions： The expression of PAR-1 is related with development and clinicopathological staging of colon cancer,the PAR-1 can be as a mark in clinical prognosis in colon cancer.