摘要
目的:观察血脉通2号颗粒对动脉粥样硬化鹌鹑血管内皮功能的影响。方法:高脂饲料造成鹌鹑动脉粥样硬化模型,用血脉通2号颗粒干预3月,观察各组鹌鹑的内皮素(ET)和一氧化氮(NO)、前列环素(PGI2)和血栓素B2(TXB2)的变化和动态平衡关系。结果:血脉通2号颗粒可提高NO、PGI2和降低ET、TXB2的水平,调节NO/ET、PGI2/TXB2的比值。结论:血脉通2号颗粒对动脉粥样硬化鹌鹑的血管内皮功能有调整作用,可能是血脉通2号颗粒治疗动脉粥样硬化的作用机理之一。
Objective： To observe the effect of Xuemaitong Granule 2on vascular endothelial function in atheroselerosis quail. Methods： Atherosclerosis quail models were established with high fat diet. Then the quail models were intervened with Xuemaitong Granule 2 to observe the changes of endothelin （ ET）; nitric oxide （ NO）, prostaeyclin （PGI2 ）and thromboxane B2 （ TXB2 ） and the dynamic balance. Results： Xuemaitong Granule 2 could enhance the NO, PGI2 and reduce levels of ET, TXB2, adjust the ratio of NO / ET, PGI2/TXB2. Conclusion： Xuemaitong Granule 2 has the role of adjusting vascular endothelial function of atheroselerosis quail, which may be one of the mechanisms in treating atherosclerosis.
出处
《河南中医》
2010年第11期1066-1068,共3页
Henan Traditional Chinese Medicine
基金
江苏省常州市科学技术委员会课题(编号:CS20092026)
