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MMP-2和TIMP-1平衡与高血压左心室重构形态的关系 被引量：4

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摘要 目的研究基质金属蛋白酶-2(MMP-2)及其抑制物基质金属蛋白酶抑制剂-1(TIMP-1)的血清水平与高血压心室重构不同形态的关系。方法对110例高血压患者和30例正常人进行超声心动图检查,按照Devereu公式计算左室重量指数及左室后壁相对厚度。根据高血压左心室重构类型分为4组(正常构型组,向心性重构组,向心性肥厚组和离心性肥厚组),并测定其MMP-2及其TIMP-1的血清水平,进行统计分析。结果与正常对照组比较,高血压各不同构型组的血清MMP-2及TIMP-1的水平均升高(P<0.05)。高血压亚组分析,与正常构型组比较,发生心脏构型改变的三组血清MMP-2水平均升高(P<0.05)。高血压各组之间TIMP-1水平的变化无统计学意义(P>0.05)。结论高血压患者发生心室重构的不同类型与血清MMP-2水平升高和MMP-2/TIMP-1平衡失调有关。
作者 石丹 黄爱京 叶青 文锦丽 梁晓萍 董少红
机构地区 暨南大学第二临床医学院 广东省深圳市人民医院第二门诊部 广东省深圳市人民医院龙华分院 广东省深圳市人民医院老年病研究所 广东省深圳市人民医院心内科
出处 《广东医学》 CAS CSCD 北大核心 2010年第16期2108-2109,共2页 Guangdong Medical Journal
关键词 基质金属蛋白酶-2 基质金属蛋白酶抑制剂-1 高血压左心室重构形态
分类号 R734.2 [医药卫生—肿瘤]
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参考文献5

二级参考文献20

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同被引文献40

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引证文献4

二级引证文献13

广东医学
2010年 第16期

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