难治性特发性血小板减少性紫癜介入治疗临床观察

Clinical research of the partial splenic embolization in the treatment of the refractory idiopathic thrombocytopenic purpura

目的探讨难治性特发性血小板减少性紫癜(ITP)行脾动脉栓塞(PSE)治疗的临床疗效。方法对我院2007年7月～2009年10月15例特发性血小板减少性紫癜内科治疗无效患者行部分脾动脉栓塞(PSE)治疗。于术前及术后1d、3d、1周、2周、1个月、3个月复查血常规。并于术前、术后1个月检测免疫球蛋白,观察其临床疗效。结果 15例患者中有12例显效(80.0%),良效2例(13.3%),无效1例(6.7%)。结论 PSE操作简单,创伤小,并发症少,保留了脾脏的免疫功能,临床疗效满意,是治疗难治性ITP安全有效的方法。

Objective To investigate the clinical effect of the partial splenic embolization in the treatment of refractory idiopathic thrombocytopenic purpura （ITP）.Methods Fifteen cases of refractory ITP were chosen from the PSE cases since July 2007 to October 2009,the blood routine exam ination were performed 1,3 days,1,2 weeks and 1,3 months after operation in all cases,the clinical therapeutic effects were observed.Results There were obvious effect in 12 cases （80.0%）,good effect in 2 cases （13.3%） and no effect in 1 case （6.7%）.Conclusion PSE is a safe and effective method to treat refractory ITP,It is time-saving,operate-simple and with fewer trauma and side effects.