期刊文献+

特发性血小板减少性紫癜骨髓巨核细胞数与预后的关系 被引量:3

Prognostic significance of bone marrow megakaryocyte in patients with idiopathic thrombocytopenic purpura
下载PDF
导出
摘要 目的探讨特发性血小板减少性紫癜(ITP)患者骨髓巨核细胞数与预后的关系。方法回顾性分析新疆医科大学第一附属医院血液科住院的260例ITP患者的预后与初诊时骨髓涂片巨核细胞的数量、原始幼稚巨核细胞百分数的关系。结果初诊时骨髓巨核细胞计数越多,预后越好,初诊时骨髓原始幼稚巨核细胞比例越高,预后越好。结论初诊时骨髓巨核细胞的数量、原始幼稚巨核细胞百分数与ITP预后有密切关系,可作为早期判断ITP预后的指标。 Objective To investigate the prognostic significance of bone marrow megakaryocyte in patients with idiopathic thrombocytopenic purpura.Methods 260ITP patients'data from our hematology department were collected and retrospectively analyzed,including the counts of the megakaryocyte and the percentage of megakaryoblast and promegakaryocyte on the bone marrow smears from diagnosis to prognosis.Results The more number of the megakaryocyte and the high proportion of megakaryoblast and promegakaryocyte at diognosis,the better of the prognosis.Conclusion The counts of megakaryocyte and the percentage of megakaryoblast and promegakaryocyte at the diognosis have close relation with prognosis of ITP patients,it can be an early index to predict prognosis of ITP patients.
出处 《新疆医科大学学报》 CAS 2010年第9期1111-1112,共2页 Journal of Xinjiang Medical University
关键词 巨核细胞 骨髓 血小板减少性紫癜 特发性 预后 megakaryocyte bonemarrow idiopathic thrombocytopenic purpura prognosis
  • 相关文献

参考文献8

二级参考文献32

  • 1刘国卿,梁晓玫,黄宗干.原发性血小板减少性紫癜患者体液免疫指标与血小板功能测定的分析[J].重庆医科大学学报,1995,20(3):176-179. 被引量:2
  • 2[1]Yang R, Han ZC. Pathogenesis and management of chronic idiopathic thrombocytopenic purpura:an update[J], Int J Hematol ,2000 ,71:18-24.
  • 3[2]Kapatkin S. Autoimmune ( idiopathic ) thrombocytopenic purpura[J]. Lancet, 1997,349:1531 - 1536.
  • 4[3]Xiao Lihua. Curative effect observation of R -globulin plus hormone to acute severe idiopathic thrombocytopenic purpura[J]. China Journal of Modern Medicine ,2000,11 (10) :85 - 87
  • 5[4]Godeau B, Zini JM, Schaeffer A, et al. High - dose Methyprednisolone is an alternative treatment for adults with autoimmune thrombocytopenic purpura refractory to intravenous immunoglobulins and o ral corticosteroids[ J]. Am J Hemato1,1995 ,48 :282 -284.
  • 6[5]Ahn YS, Byrnes JJ, Harrington WJ, et al. The treatment of idiopathic thrombocytopenia with vinblastine -loaded platelets[J]. N Engl J Med,1978,298:1101 - 1107.
  • 7[6]Emilia G, Messora C, Longo G, et al. Long -term salvage treatment by cyclosporin in refractory autoimmune haematological disorders [J].Br J Haematol, 1996,93:341 - 344.
  • 8[7]Katkhouda N, Mayor E. Laparoscopic Splenectomy[J]. Surg Clin North AM ,2000,80:1285 - 1297.
  • 9[8]Bell WR. Long - term outcome of Splenectomy for idiopathic thrombocytopenic purpura[J]. Semin Hematol,2000,37( 1 suppl 1 ) :22 -25.
  • 10[9]Calverley DC, Jones GW, Kekton TG, et al. Splenic radiation for corticosteroid- resistant immune thrombocytopenia[J]. Ann Intern Med, 1992,16:977 - 981.

共引文献79

同被引文献22

  • 1Gemsheimer T. Chronic idiopathic thrombocytopenic purpu- ra.. Mechanisms of pathogenesis [J]. Oncologist, 2009, 14(1): 12-21.
  • 2Semple JW, Provan D, Garvey MB, et al. Recent prog- ress in understanding the pathogenesis of immune thrombo- cytopenia [J]. Cure Opin Hematol, 2010, 17(6): 590-595.
  • 3Lied GA, Berstad A. Functional and clinical aspects of the B-cell-activating factor (BAFF): a narrative review [J]. ScandJImmunol, 2011, 73(1): 1-7.
  • 4Clines DB, Bussel JB, Lieboman HA, et al. The ITP syndrome., pathogenic and clinical diversity [J]. Blood, 2009, 113(26): 6511-6521.
  • 5Gernsheimer T. Chronic idiopathic thrombocytopenic purpura: mecha- nisms of pathogenesis[ J]. Oncologist,2009,14( 1 ) : 12 - 21.
  • 6Semplc JW, Provan D,Garvey MB,et al. Recent progress in understand- ing the pathogenesis of immune thrombocytopenia [ J ]. Curt Opin He- matol, 2010,17 ( 6 ) :590 - 595.
  • 7Cines DB, Bussel JB, Liebman HA ,et al. The ITP syndrome: pathogenie and clinical diversity [ J ]. Bloxt ,2009,113 ( 26 ) :6511 - 21.
  • 8吴蓓倩,朱萍,牛强,陈字,谢毅.血小板自身抗体的流式细胞检测与意义[J].医学研究杂志,2008,37(11):79-80. 被引量:6
  • 9李婉丽,蒋小梅,杨海霞,张本山,吴攀,郑敏翠,宋国才,石淑华.儿童过敏性紫癜305例临床回顾性分析[J].中国皮肤性病学杂志,2009,23(12):810-812. 被引量:7
  • 10王春燕,朱效娟,侯明,石艳,彭军,孙建芝,秦平,冀学斌,王琳,王谦.大剂量地塞米松对特发性血小板减少性紫癜患者B细胞活化因子及调节性T细胞的影响[J].中华血液学杂志,2010,31(3):164-167. 被引量:16

引证文献3

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部