恩再适PCEA给药治疗腰椎间盘突出症的临床观察

Clinical observation of PCEA ex-sik in treatment in the nerve root pain caused by the waist lumbar intervertebral disc protrusion

目的观察恩再适PCEA给药治疗腰椎间盘突出症的临床疗效及安全性。方法 40例腰椎间盘突出症的患者,随机分为恩再适组和对照组,每组20例,除了口服甲钴胺胶囊1mg,鲁南贝特2片,乐松60mg,各2次/d外,恩再适组给予恩再适6ml+0.1%罗哌卡因200mg加入生理盐水至200ml、对照组0.1%罗哌卡因200mg加入生理盐水至200ml。2组均使用持续硬膜外皮下隧道PCA技术(PCEA)治疗,使用处方为硬膜外持续输注1.5～2.0ml/h,追加2ml/次,间隔时间为15min,平均10d为一疗程。采用视觉模拟评分(VAS)评分法比较2组痛觉差异。结果恩再适组治疗后VAS评分(1.31±0.62)较治疗前VAS评分(6.82±1.33)明显降低,差异有统计学意义(P<0.01);对照组治疗后VAS评分(1.45±0.92)较治疗前VAS评分(6.88±0.96)明显降低,差异有统计学意义(P<0.01);恩再适组和对照组治疗麻木、冷感等症状均有效果,恩再适组优于对照组(P<0.05)。结论恩再适治疗腰椎间盘突出症有效率高,而且安全性较好。

Objective The clinical observation on the therapeutic effect and safety of PCEA ex-sik in the treatment of the nerve pain caused by lumbar intervertebral disc protrusion.Methods 40cases of nerve pain caused by lumbar intervertebral disc protrusion were randomly assigned into two groups with 20cases each.For both groups,patients orally taken 1mg Mecobalamin capsule,2Lunanbeite tablets,60mg Le Song twice a day.NSAIDs was given in both groups.In addition to 0.1%ropivacaine used in the control group,6ml analgecine and 0.1%ropivacaine were added in the ex-sik group.Both groups flow 1.5～2.0 ml/h by epidural injection,added 2ml every 15minutes and were on an average of 10days for a course of treatment to relieve pain.Meanwhile,the index of VAS scores was recorded.Results Significant pain-relief,improved daily life ability,higher self-confidence could be observed in both groups.The average VAS scores were significantly decreased（P〈0.01）.Whereas the improvement in numbness and sense of coldness in the therapy group was higher than the control group（P〈0.05）.Conclusion Ex-Sik in treating nerve pain caused by the waist lumbar intervertebral disc protrusion is effective and safe.