T淋巴细胞协同刺激分子CD_(28)和CD_(152)在重症肺炎发病机制中的作用研究

Function of T lymphocyte-associated costimulatory molecules CD_(28) and CD_(152) in the pathogenesis of severe pneumonia

目的:探讨T淋巴细胞相关协同刺激分子CD28和CD152在重症肺炎发病机制中的作用。方法:选取50例重症肺炎患者(重症肺炎组)和50健康查体者(正常对照组)外周静脉血,采用流式细胞仪对T淋巴细胞协同刺激分子(CD28、CD152)进行检测。结果:重症肺炎组患者CD28/CD152值与正常对照组比较显著减少,比较差异有统计学意义(P<0.05);CD28CD3/CD3、CD152CD3/CD3值与正常对照组比较显著上升,比较差异有统计学意义(P<0.05)。结论:重症肺炎外周血T淋巴细胞相关协同刺激分子CD28、CD152表达异常,并参与了重症肺炎发病的病理生理过程。

Objective To observe the function of T lymphocyte-associated costimulatory molecules CD28 and CD152 in the pathogenesis of severe pneumonia（SP）.Methods The peripheral blood from 50 cases of patients with SP（SP group）and 50 healthy subjects（control group）was collected;The T lymphocyte-associated costimulatory molecules CD28 and CD152 were detected by flow cytometry.Results The CD28/CD152 value of SP group decreased significantly,compared with the control group the difference was significant（P〈0.05）;The CD28CD3/CD3 and CD152CD3/CD3 value of SP group increased significantly,compared with the control group the difference was significant（P〈0.05）.Conclusion The T lymphocyte-associated costimulatory molecules CD28 and CD152 have abnormal expression,and the CD28 and CD152 involve in the process of pathogenesis of SP.