普罗布考在老年不稳定型心绞痛患者治疗中的作用

The effect of probucol in the treatment of unstable angina in senior patients

目的:探讨普罗布考对不稳定型心绞痛(UA)老年患者血浆超敏C-反应蛋白(hs-CRP)和颈动脉粥样硬化的影响机制。方法:测定30例UA在常规治疗基础上加服普罗布考500mg/d,治疗6个月及12个月前后血浆hs-CRP浓度及经彩色多普勒测定的颈动脉内膜厚度、血流参数及颈动脉斑块变化,并与常规治疗30例作为对照组。结果:普罗布考在老年不稳定型心绞痛患者治疗中疗效确切。结论:普罗布考对防治不稳定性心绞痛早期动脉硬化及稳定斑块起着重要作用。

Objective To evaluate the effects of probucol on serum hypersensitive C-reactive protein（hs-CRP） and carotid arteriosclerosis plaque in senior patients with unstable angina（UA）.Method Thirty UA patients were given routine therapy and 500 mg/d probucol to detect serum hs-CRP concentration and intima-media thickness（IMT）,blood flow parameter and carotid arteriosclerosis plaque before and after treatment for 6 and 12 months by Doppler ultrasonography.Results After treatment for 6 months,serum hs-CRP concentration,both carotid IMT and plaque size in 30 UA patients were significantly lower than that before treatment（P 0.05）,and carotid parameters were improved,especially after 12 months,compared to those of routine therapy controls and before treatment（P 0.05）.Conclusion Probucol could play an important role in preventing and treating early arteriosclerosis and stabilizing plaque of UA.