^(13)CO_2淀粉呼气试验测定甲状腺机能亢进症的淀粉代谢

Starch metabolism in patients with hyperthyroidism studied with 13 CO 2 breath test

目的用１３ＣＯ２淀粉呼气试验的方法，定量测定甲状腺机能亢进症（甲亢）病人的淀粉代谢。方法用１３ＣＯ２玉米淀粉呼气试验测定３７例甲亢患者淀粉代谢，并与２１例健康志愿者（对照组）相比较。结果甲亢患者口服１００ｇ玉米淀粉后，１３ＣＯ２的排出量在（１８１±３０）分达到高峰，显著早于对照组〔（２０５±３９）分，Ｐ＜０．０５〕，但１３ＣＯ２峰值两组无显著性差异（Ｐ＞０．０５）。１３ＣＯ２累积排出量３０分、６０分、９０分时均非常显著高于对照组（Ｐ＜０．０１），１２０分、１５０分及１８０分时仍显著高于对照组（Ｐ＜０．０５），但２１０分至３６０分的１３ＣＯ２累积排出量较对照组无统计学差异（Ｐ＞０．０５）。结论甲亢患者淀粉的代谢在１８０分钟前显著加快，峰值与正常对照无差异但时间明显提前，６小时淀粉总代谢两组间无明显差异。

Objective Tostudythestarchmetabolisminhyperthyroidismpatientswith noninvasive 13 CO 2 breath test. Methods Samples of 13 CO 2 expiration were collected every 30 min over a period of 6hr after starch intake from 37 hyperthyroidism patients and were compared with those from 21 healthy volunteers. Results Afteringestionof 100g ofcornstarch,bothpeaktime Tmax:(181±30)min andcumulative 13 CO 2 expiration between 0～180min in hyperthyroidism patients were significantly faster and higher than those of normal controls (P<0.05), but neither the cumulative 13 CO 2 expiration between 210～360min nor the peak values (C max ) were statistically different between these 2 groups (P>0.05). Conclusion This study indicates that starch metabolism during 0～180min in patients with hyperthyroidism is faster than that of healthy control. The 13 CO 2 starch breath test is an effective test in quantitative evaluation of starch metabolism in vivo.