肾移植患者血清抗中性粒细胞胞浆抗体检测的临床意义

The clinical significance of anti neutrophil cytoplasmic antibodies in kidney transplantation

目的:评价在肾移植急性血管性排斥反应诊断中用间接免疫荧光法(IF)检测血清抗中性粒细胞胞浆抗体(ANCA)和ELISA法检测血清抗髓过氧化物酶抗体(MPO-ANCA)同步检测的意义。方法:回顾性总结了41例经肾活检确诊的肾移植排斥反应患者ANCA的检出率,了解AN-CA阳性的肾移植排斥反应的种类及其临床病理特点。结果:141例肾移植患者有11例血清IF-ANCA阳性,有15例血清MPO-ANCA阳性。2IF-ANAC和MPO-ANCA同时阳性主要见于肾移植急性血管性排斥反应。结论:血清MPO-ANCA和IF-ANCA同步检测可以提高对肾移植急性血管性排斥反应诊断价值。

Purpose:Study the clinical or pathological feature in kidney transplantation with ANCA positive.Methods:We performed a retrospective study of the positive rate of ANCA among 41 patients with kidney transplantation rejection, compared the significance of simultaneous study of IF ANCA and MPO ANCA in kidney transplantation.Results:①The number of IF ANCA positive were 11 cases in 41 patients,while MPO ANCA positive were 15 cases.②The simultaneous positive of serum IF ANCA and MPO ANCA were in kidney transplantation acute vasculitis rejection.Conclusions:The simultaneous positive of IF ANCA and MPO ANCA may increase the diagnosis of kidney transplantation vasculitis rejection.