婴幼儿肝炎综合征诊疗中血清总胆汁酸测定的临床意义

目的：探讨血清总胆汁酸（TBA）在婴幼儿肝炎综合征（HIS）中的诊疗价值。方法：采用全自动酶循环法分析技术对52例婴幼儿肝炎综合征患儿及60例正常对照组的婴幼儿进行空腹血清TBA及其他肝功能6项指标测定。结果：正常对照组TBA值频数呈正偏态分布，经对数转换后，正态性D检验呈对数正态分布，参考值范围：0-11．6umol／L。患儿组血清TBA值范围：1．1—239．6umol／L，异常率达90．4％，与正常对照组比较，差异显著（P〈0．05）；患儿组TBA与血清碱性磷酸酶（ALP）、直接胆红素（DBIL）、1-谷氨酰转移酶（γ-GT）水平有良好的相关性，且TBA的灵敏度和特异性均优于常规指标。结论：血清TBA测定对婴幼儿肝炎综合征的诊断、疗效观察及预后判断均有重要意义。

ObjectivesTo studying the value of serum total bile acid （TBA） in the diagnosis and treatment of infantile hepatitis syndrome. Methods Serum TBA and other liver function related items were measured by automatic enzymatic assay techniques in 52 with infantile hepatitis syndrome patients and 60 normal infants. Results The frequency of TBA value present skewness distribution in normal control group. After logarithm transformation, The normality D examination assumes the logarithm normal distribution. In the control group, the serum TBA level was 0--11.6 umol/L. TBA level was abnormal in 90.4% patients and the values were 1.1--239.6 umol/L. The difference was significant between the two groups （P 〈 0.05 ）. The TBA levels were well-related to those of ALP, DBIL and γ-GT; and TBA was better than others in sensitivity and specificity, [Conclusions] Serum TBA level is important in evaluating the diagnosis, treatment, and prognosis of infantile hepatitis syndrome.