女性生殖道支原体感染与不孕症的关系及药敏分析

Correlation between female genital infection and infertility and drug sensitivity analysis

目的探讨女性生殖道支原体感染与不孕症之间的关系及对11种抗生素的敏感率,指导临床明确诊断,合理用药。方法随机选择2007年至2009年来长治市妇幼保健院就诊的女性不孕症患者360例,进行宫颈分泌物支原体培养和药敏试验。结果 360例宫颈分泌物标本中检出解脲支原体(Uu)阳性者161例、人型支原体(Mh)阳性者3例、解脲支原体(Uu)+人型支原体(Mh)混合阳性者29例;对阳性标本都做了11种抗生素的药敏试验,其中交沙霉素敏感率为93.47%、美满霉素敏感率为92.00%、强力霉素敏感率为90.21%、克拉霉素敏感率为83.69%、甲砜霉素敏感率为73.91%、环脂红霉素敏感率为61.95%和阿奇霉素敏感率为53.26%等。结论女性不孕症伴随高发的生殖道支原体感染,支原体感染与不孕症可能有关;长治地区生殖道支原体对交沙霉素、美满霉素、强力霉素、克拉霉素、甲砜霉素敏感性较高,环脂红霉素、阿奇霉素次之,对红霉素、罗红霉素敏感性较低,对环丙沙星、左氧氟沙星敏感性很低。

Objective To explore the relationship between female genital tract mycoplasma infection and infertility and the sensitivity rates of the pathogen to 11 kinds of antibiotics,so as to guide clinical diagnosis and rational drug use.Method 360 cases of female infertility during 2007 and 2009 in our hospital were randomly selected for a detection of mycoplasma in cervical secretions and the drug susceptibility.Result Of the 360 cases,161 cases were Ureaplasma urealyticum（Uu） positive,3 cases were Mycoplasma hominis（Mh） positive,and 29 cases were Uu ＋ Mh positive.Durg susceptibility test was performed to all the positive samples with 11 kinds of antibiotics,in which the sensitivity to josamycin,minocycline,doxycycline,clarithromycin,thiamphenicol,central fat erythromycin and azithromycin was 93.47%,92.00%,90.21%,83.69%,73.91%,61.95% and 53.26%,respectively.Conclusion The high incidence of female infertility associated with reproductive tract infection and mycoplasma infection may be related to infertility;The genital mycoplasma in Changzhi area are highly sensitive to josamycin,minocycline,doxycycline,clarithromycin and thiamphenicol,followed by Central fat erythromycin and azithromycin.The pathogen is less sensitive to erythromycin and roxithromycin,and the sensitivities to ciprofloxacin and levofloxacin are the lowest.