丹参注射液联合三联疗法治疗胃溃疡

Clinical efficacy of Danshen injection combined with triple therapy in treatment of gastric ulcer

目的 探讨三联疗法联合丹参注射液治疗胃溃疡的疗效.方法 选择经胃镜检查确诊为Hp阳性的胃溃疡患者70例作为研究对象,随机分为观察组34例,对照组36例.对照组采用奥美拉唑20 mg＋阿莫西林1.0 g＋克拉霉素0.5 g,2次/d治疗,疗程7 d;观察组在对照组的基础上给予丹参注射液250 ml,1次/d治疗,静脉滴注,疗程7 d,观察比较两组的疗效及不良反应.结果 观察组的总有效率为97.06%（33/34）,明显高于对照组的75.00%（27/36）（P〈0.05）.治疗前两组临床症状积分差异无统计学意义,治疗6周后两组临床症状积分均较治疗前明显减少（P〈0.01）,两组间差异有统计学意义（P〈0.05）.观察组出现食欲减退2例,对照组出现恶心3例、食欲减退1例,头晕、头痛1例,均症状较轻,可耐受,无需处理,疗程中及停药后自行消失.结论 奥美拉唑三联疗法联合丹参注射液治疗胃溃疡具有溃疡愈合率高、症状消失快等优点,值得临床推广和应用.

Objective To investigate the effect of triple therapy treatment combined danshen injection in treatnent of gastric ulcer. Methods Period gastroscopy 1 Hp-positive gastric ulcer diagnosed 70 patients as subjects,34 patients were randomly divided into two groups,control group 36 cases. Control group,omeprazole 20mg ＋ amoxicillin clarithromycin 1.0g ＋ 0.5g,2 times / d and treated for 7d,the observation group based in the control group given Danshen injection fluid 250ml, 1 times/d treatment intravenous infusion 7d,observe and compare the efficacy and side effects two groups. Results The total effective rate was observed 97.06% （34/33）, significantly higher than the total effective rate 75.00% （ 27/36）, by statistical analysis, the total effective difference between the two groups was significant （P 〈 0. 05）. Before treatment, clinical symptom score difference between the two groups not significantly,after 6 weeks of treatment,clinical symptom score than those in the two groups before treatment significantly reduced（ P 〈0. 01 ） ,and the difference between the two groups was significant（ P 〈0. 05 ）. Diminished appetite and the observation group 2 patients,nausea in 3 cases the control group, 1 case of anorexia, dizziness, headache in 1 case,were mild and tolerable, without treatment, treatment of and withdrawal go away. Conclusion Triple therapy omeprazole combined Danshen injection treatment of gastric ulcer lidocainefor with good ulcer symptoms disappeared and quick, was worthy of promotion and application.