还原型谷胱甘肽对毒鼠强中毒大鼠的干预作用

Interventional Effect of Reduced Glutathione on Rats With Acute Tetramine Poisoning

目的:观察还原型谷胱甘肽(GSH)对急性毒鼠强(TET)中毒大鼠的干预作用。方法:将30只大鼠随机分为假手术组、对照组和GSH组,每组10只。通过毒鼠强灌胃染毒大鼠制备动物实验模型,染毒前30min对照组和GSH组分别给予生理盐水及GSH(1000mg/kg)腹腔注射。观察各组大鼠的死亡率,肝、肾功能和组织细胞病理学改变,肝肾细胞凋亡水平。结果:GSH能明显降低急性毒鼠强中毒大鼠的死亡率(P<0.05),改善肝功能(P<0.01),降低肝肾细胞凋亡水平。结论:GSH对急性毒鼠强中毒有治疗作用。

Objective：To observe the interventional effect of reduced glutathione （GSH） on rats with acute tetramine （TET） poisoning.Methods：Thirty Spraque-Dawley rats were randomly divided into sham-operated group,control group and GSH group （n=10 for each group）.Sodium chloride or GSH （1000 mg/kg） were administrated by intraperitoneal injection 30 minutes before the acute poisoning animal model was established with tetramine in control and GSH group.The mortality,liver and renal function,histopathological changes,levels of apoptosis of liver and kidney cells were investigated.Results：GSH can obviously decreased the mortality of acute tetramine poisoning （P0.05）,improve liver function （P0.01）,decrease levels of liver and renal cell apoptosis.Conclusion：GSH can effectively antagonize the acute toxicity of tetramine in rats.