乳复康治疗乳腺增生病的作用机制

Effects of Rufukang(RFK)on the expression level of GnRH mRNA and ER mRNA in rats with mammary hyperplasia

目的:通过乳复康对乳腺增生模型大鼠雌激素受体(ER)及下丘脑促性腺激素释放激素(GnRH)mRNA表达水平的调节作用研究,探讨乳复康治疗乳腺增生病的作用机制。方法:将SD大鼠随机分为空白组、模型组和RFK组,检测各组动物GnRH及ERmRNA表达水平。结果:模型组GnRH及ERmRNA表达高于空白对照组(P<0.01);乳复康组与模型组比较,GnRH及ERmRNA表达水平均明显下调(P<0.05);乳复康组与空白组比较,ERmRNA表达水平无显著性差异(P>0.05)。结论:乳复康有效降低模型动物的GnRH及ERmRNA表达,从而对乳腺增生病发挥治疗作用。

OBJECTIVE To investigate the regulative effects of Rufukang（RFK） on the serum levels of GnRH mRNA and ER mRNA in rats with mammary hyperplasia. METHODS The model of mammary hyperplasia was established with estrogen and progestogen,and the levels of GnRH and ER mRNA were measured in all groups. RESULTS The levels of GnRH and ER mRNA in model group were higher than that in normal group （P〈0. 01 ）. The levels of GnRH and ER mRNA in RFK group were lower than that in model group （P〈0. 05）. The expression levels of ER mRNA in RFK group were no difference than that in normal group （P〉0. 05）. CONCLUSION RFK can reduce the expression levels of GnRH mRNA and ER mRNA in rats with mammary hyperplasia remarkably, so as to treat mammary hyperplasia.