clock基因rs1801260多态性与抑郁症的关联分析

Association of Clock Gene rs1801260 Polymorphism with Depressions

目的:探讨clock基因与汉族人群抑郁症的关联。方法:用Snapshot SNP分型技术对155例抑郁症患者(其中包括133名抑郁症睡眠障碍者)和150名正常对照进行clock基因rs1801260位点分型,比较两组该基因多态性基因型和等位基因频率的差异。结果:与对照组相比,患者组rs1801260多态性的基因型和等位基因的频率差异无统计学意义(P>0.05);对rs1801260多态性二种基因型C/T、T/T抑郁症的临床资料比较,显示HAMA总分差异具有统计学意义(t=2.012,P=0.047),其他各项没有明显差异(P>0.05)。结论:clock基因rs1801260多态性可能与中国汉族抑郁症的发病无关联,但与抑郁症的焦虑程度可能关联。

Objective： To explore the association of clock gene with depression in Han Chinese.Methods： The clock gene rs1801260 was genotyped by Snapshot SNP technique in 155 depressions（includng 133 dpressions with insominia） and 150 normal controls.The genotype and allete gene frequency in the two groups were compared.Results： There were no significant differences in genotype and allete gene in clock gene rs1801260 between depressions and healthy controls（P0.05）;As compared with the depression’s clinical data of two genotypes of the rs1801260 polymorphism C/T,T/T,there was statistically significant difference in HAMA total score（t=2.012,P=0.047）,but no other significant difference（P0.05）.Conclusion： There is no association of clock gene rs1801260 polymorphism with the incidence of depressions in Han Chinese,but maybe association with the level of anxiety in depressions.