性激素对心脏重构的影响

Effects of gender hormone on cardiac remodeling

性别对心脏重构有着微妙而独特的影响。心脏重构是指发生于心肌损伤之后的分子和细胞事件所导致的心脏各腔室形态、内径和功能改变。女性和男性针对损伤所产生的心脏重构反应不同,雌激素和睾酮对于心肌细胞和心肌成纤维细胞的分子效应迄今尚未充分阐明。本文就性激素对心脏重构影响的机制做一综述。

Gender plays a subtle and specific role in cardiac remodeling. Cardiac remodeling is defined as an alteration in anatomy,inter diameter and function of cardiac chambers caused by a series of molecular and cellular events after injury to the heart. The different reaction to post-injury cardiac remodeling between the both genders and the molecular effects of estrogen and testerone on myocardiocytes and myofibroblasts remain to be further elucidated. The mechanisms underlying influence of sex hormones on cardiac remodeling was summarized in this paper.