中医预防方案干预社区流感的随机对照研究

Randomized and control study on TCM preventive plan for intervening community influenza

目的评价中药预防方案对社区人群流感发病的预防效果,为中医药防控流感的有效性提供循证依据。方法在北京市东城区社区选择3 166例自然人群,收集资料完整能进入最后统计分析的受试者共3 078例,通过按照年龄及意愿随机方法分为成人干预组、成人对照组、老人干预组和老人对照组,干预组口服中药成人预防方或老人预防方,对照组不予药物干预,观察流感发病情况。结果经统计学分析,成人干预组和对照组的整体比较及成人无甲流疫苗接种人群、无普通流感疫苗接种人群比较,中药干预组流感样病例的发病率均低于对照组,均有统计学差异。在体重指数<30的成人组中,干预组和对照组的发病率比较有统计学差异,中药干预组流感样病例的发病率均低于对照组,而在体重指数>30成人组中则无统计学差异;老人干预组和对照组,无论整体发病率比较,或是否有接种疫苗、体重指数等影响因素,流感样病例发病率比较均无统计学差异。结论初步说明中药干预具有预防流感发病的作用。

Objective To evaluate the preventive effect of TCM preventive plan on influenza in community people group,and to provide the base of evidence-based medicine for controlling influenza with Chinese medicine.Methods Among 3166 natural persons from Dongcheng District of Beijing after collecting completed materials,there were 3078 enclosed into final statistical analysis.All persons were randomly divided into adult intervention group,adult control group,senile intervention group and senile control group according to the age and will.The two intervention groups were given oral TCM preventive formula for adult or aged,and the control groups were not given any intervention medicinal.The occurrence of influenza were observed.Results After statistical analysis,the morbidity of influenza was lower in the adult intervention group compared with that in the adult control group,the group without inoculation of Influenza A Vaccine and the group without ordinary inoculation of influenza vaccine.The difference was statistically significant.In the adult groups（with the body index below 30） the morbidity was lower in the adult intervention group compared with that in the adult control group and the difference was statistically significant,but that in the adult groups（with the body index above 30） was not statistically significant.The comparison in the morbidity,inoculation of influenza vaccine and body index between the aged intervention group and aged control group showed that there was no statistical difference.Conclusion The study has proved initially that TCM intervention has the effect of preventing the occurrence of influenza.