机械通气后儿童远期肺功能改变

Long-term Lung Function in Children after Mechanical Ventilation Changes

目的:分析新生儿机械通气对反复呼吸道疾病和远期肺功能改变的影响。方法:新生儿期用呼吸机机械通气治疗40例患儿,7年后随访,了解并作肺功能情况并分析。结果:患儿出生后3年肺功能改变,40例中反复呼吸道症状的28例(70.0%),其中有呼吸机相关性肺炎15例(37.50%),肺出血5例(12.50%),败血症3例(7.50%),颅内出血2例(5.0%),气胸2例(5.0%),支气管发育不良1例(2.50%)。早产儿与足月儿并发症发生率有显著差异。机械通气时间(?)7d组与机械通气时间<7天组常见并发症发生率有显著差异。早产儿和机械通气时间(?)7d组的并发症明显高于足月儿和机械通气时间<7天组。结论:新生儿机械通气可影响远期肺功能。儿童期反复呼吸道疾病可能与肺损伤后支气管反应性增高有关,可致哮喘发作。

Objective：Analysis of neonatal mechanical ventilafion on respiratory disease and long-term repeated changes of lung function.Methods：Neonatal mechanical ventilation with a ventilator 40 chiidren,7 years follow-up,and for lung function to undcrtand and analyze.Results：Lung function in Children change after birth,3 years,40 cases of/ecurrent respiratory symptoms in 28 eases （70：0%）iincluding ventilator-associated pneumonia in 15 cases（37.50%）,pulmonary hemorrhage in 5 cases （!2,50%）,sepsis in 3 cases （7.50%）,intracranial hemorrhage in 2 cases （5.0%）,pneumothorax in 2 cases （5.0%） bronchial dysplasia in 1 case （2.50%） Preterm children and term children complication rates were significantly different.Mechanical ventilation 〉Td group and mechanical ventilation time 〈7days group common complication rate were significantly different. Preterm children and mechanical ventilation _〉Td group was significantly higher than full-term childran,and Complications of mechanical ventilation time〈7days group.Conclusion：disease and lung injury may bronchial responsiveness increased,which can be induced asthma attacks.