综合疗法治疗非酒精性脂肪性肝炎的疗效观察

Effect of Comprehensive Therapies on Non-alcoholic Steatohepatitis(NASH)

目的:评价肝安汤对非酒精性脂肪性肝炎(NASH)的疗效。方法:94例符合NASH诊断标准的患者随机分为2组,即肝安组和综合组,肝安组给予肝安汤口服;综合组除口服肝安汤外,还辅以饮食调节和运动疗法,疗程均3个月。在治疗前后分别观察症状和体征的变化,检测体重指数(BMI)、腰围/臀围比(WHR)、计算肝脏的B超积分、检查血脂、肝功能和空腹血糖(FBG)。结果:经3个疗程治疗后,两组病人BMI、WHR、血脂、肝功能、FBG和B超积分均显著改善,但综合组优于肝安组,2组的总有效率分别为93.61%和,78.72%P<0.01。结论:肝安汤治疗NASH有确切疗效,能降低血脂、FBG,减轻脂肪肝、改善肝功能,如同时配合饮食调节和运动疗法则疗效更佳。

Objective：This study was designed to assess the therapeutic effect of Gan An decoction on non-alcoholic steatohepatitis（NASH）.Methods：94 NASH patients were randomly divided into Gan An group or combined group,the first group were treated with Gan An decoction,a mixture composed of more than ten Chinese traditional medicine, and the second group combined Gan An decoction therapy with diet restriction and exercise,each for three months.Preand post treatmants,the data of clinical symptom and physical sign, body mass index（BMI）,waist to hip ratio（WHR）,B mode ultrasonographic image score of liver,blood lipids, liver function tests and Fasting blood sugar （FBG） were serially measured.Results：Alter three-month treatments,both Gan An group and combined group showed desirable effects in BMI. WHR. blood lipids,liver function. FBG and hepatic B mode ultrasonographic score,but the combined group revealed superiority over the Gan An group,the total effective rate was 93.61% and 78.72%in combined group andin Gan An group rgspectively,P〈0.0LConeluston： Gan An decoction is a effective drug which is able to reduce blood lipids. FBG. relieve fattyliver and improveliver function in treating nonalcoholic steatohepatitis,and the effectiveness would further increase when it combined with diet restriction and appropriate exercise.