基于数学模型血糖监控仪的应用研究

Application and Development of Mathematical Model-based Blood Glucose Regulator

血糖监控仪能自动调节血糖浓度使其处于正常范围,不需人工干预。此系统由三个核心部件组成:连续血糖监测系统,胰岛素输入系统和联接前两者的控制算法。其中,血糖连续监测系统最大的挑战便是葡萄糖传感器的精度。基于胰脏胰岛素分泌模型、葡萄糖吸收模型,提出一种胰岛素比例微分(PD)控制器对血糖浓度进行调节,并运用软件仿真和系统样机进行实验。基于实验结果,文中提出的胰岛素控制器可实现对胰岛素输入的控制,对异常血糖浓度进行报警,优化血糖控制。

Blood glucose regulator can regulate blood glucose level automatically within the normal range without manual intervention. The system is composed of three essential components：continuous blood glucose monitoring system,insulin delivery system and a control algorithm. The precision of the blood glucose sensor is the greatest challenge for the development of the continuous blood glucose monitoring system. Based on the models of insulin secretion and absorption of glucose,an insulin PD controller is suggested in this paper to regulate the blood glucose followed by software simulation and prototype implementation tests. According to the experiments results,the insulin controller suggested is able to achieve the control of the insulin input,alarm the abnormal glucose concentration and improve blood glucose regulation.