中国南方食管癌高低发区饮用水致突变性的比较研究

Comparative Study on The Mutagenicity of Drinking Water in High and Low Risk Areas for Esophageal Cancer in Southern China

目的探讨南方食管癌高、低发区饮用水污染在食管癌发病过程中的作用。方法采用蚕豆根尖细胞微核技术分别检测南澳县各镇与佛山各区饮用水的微核千分率(MCN‰)及污染指数(PI),同时用蒸馏水设立阴性对照,用重铬酸钾设立阳性对照。结果①南澳县各镇饮用水的微核千分率与蒸馏水比较,均显著升高(P<0.05),且饮用水污染的程度与食管癌的病死率有关。②佛山市各区饮用水的微核千分率与蒸馏水比较,无显著性差异(P>0.05)。结论提示饮用水污染可能是食管癌的危险因素。

Objective To esplore the role of the drinking water pollution in the progression of esophageal cancer（EC）in the high and low risk areas for EC in southern China.Methods The drinking water from Nanao county and Foshan city was collected and detected the micronucleus frequences of vicia faba root tip cells（MCN‰）and pollutant indexes（PI）by Vicia-micronucleus test（VAMCN）,regarding distilled water as a negative control and potassium dichromate solution as a positive control.Results ①The drinking water from Nanao county resulted in higher micronucleus rates,and there was remarkably different compared with distilled water,and the degree of the drinking water pollution was correlated to the mortality of EC②The drinking water from Foshan city resulted in higher micronucleus rates,but there was no different compared with distilled water.Conclusion The drinking water pollution could be the causative factor of the esophageal carcinogenesis.