静脉应用胺碘酮治疗阵发性房颤的临床观察

Clinical observation of intravenous amiodarone to paroxysmal atrial fibrillation

目的观察静脉应用胺碘酮对阵发性心房颤动的疗效。方法 61例阵发性房颤的患者,首剂静脉注射150mg,10min内注入,继之以0.5mg/分维持静脉泵入,30min未转复为窦性心律且心室率仍快者,追加静脉注射150mg。结果 15例4小时内转复窦性心律,18例4～12小时后转复窦性心律,13例12～48小时后转复窦性心律。转复率为83.6%;用药期间,2例出现窦性心动过缓,无低血压、心衰加重、心绞痛加重及QT间期延长等不良反应。结论静脉应用胺碘酮治疗阵发性心房颤动安全有效。

Objective To observation of the clinical efficacy and safety of intravenous amiodarone to paroxysmal atrial fibrillation in patients with cardiac disease.Methods 61 patients with atrial fibeillation were observed.After an intravenous load,intravenous amiodarone was administrated continuously.Starting doses for patients was 150 mg and inject ends in 10 min.The speed of continuously-pumped amiodarone was 0.5mg/min.After 30min,sinus rhythm and ventricular rate were fasterstill.Patients were given additional doses of amiodarone（150 mg）.Results Atrial fibrillation was reverted to sinus rhythm with 48 hour in 51 of 61 cases（86.3%）.Sinus bradycardia occurred in 2 patients.The drug can not cause adverse reactions inclding hypotension,worsen heart failure,worsen angina and Long QT.Conclusion Intravenous amiodarone is effective and safe in the treatment of paroxysmal atrial fibrillation in patients.