摘要
目的:观察大鼠心肌缺血再灌注损伤(MIRI)中钙调神经磷酸酶(CaN)活性的变化,以及参麦注射液(SMI)对其的影响。方法:24只大鼠随机分为3组(n=8):假手术组、心肌缺血再灌注模型组和参麦注射液治疗组,检测各组在缺血30min,再灌注2h后心肌CaN的变化。结果:模型组大鼠与假手术组相比,心肌CaN活性明显升高(P<0.01);与模型组相比,参麦治疗组大鼠心肌CaN活性明显降低(P<0.01)。结论:参麦注射液可以抑制大鼠心肌的CaN活性,从而对缺血再灌注心肌起到保护作用。
Objective：To investigate the effects of Shenmai injection（SMI）on activity of calcineurin during myocardium ischemia-reperfusion in rats.Methods：24 rats were divided randomly into 3 groups（n=8）：sham-operated group,myocardial ischemia-reperfusion（MIR）model group and SMI group.The activity of calcineurin（CaN）was checked after 30 minutes ischemia and 2 hours reperfusion.Results：Compared with that of sham-operated group,the activity of CaN increased significantly（P0.01）in MIR model group;and compared with that of MIR model group,the activity of CaN decreased significantly（P0.01）in SMI group.Conclusion：Shenmai injection can protect the myocardial function by decreasing CaN activity on ischemia-reperfusion myocardium in rats.
出处
《河北北方学院学报（医学版）》
2010年第5期10-12,共3页
Journal of Hebei North University:Medical Edition
基金
河北省科学技术研究与发展指导计划项目(编号:062761366)
关键词
参麦注射液
心肌缺血
再灌注损伤
Shenmai injection
Myocardial ischemia
Reperfusion injury
