茵栀黄口服液提取工艺研究

Study on Extraction Process of Yinzhihuang Oral liquid

目的:探讨茵栀黄口服液的最佳提取工艺条件。方法:以黄芩苷含量和干浸膏得率为评价指标,考察加水倍数、提取时间、提取次数和醇沉浓度4个影响因素,采用正交试验设计法对茵栀黄口服液提取工艺进行优选。结果:优选得到的最佳提取工艺为加10倍量水,提取3次,每次1h,醇沉浓度为60%。结论:该优化工艺条件科学合理,提取效率高,稳定可行。

Objective： To investigate the best extraction process of Yinzhihuang oral liquid. Methods： The content of baicalin and dry extract yield were served as evaluation indexes for examining multiple - sum of adding water, extraction time, extraction frequency and alcohol precipitation concentration, and the extraction process of Yinzhihuang oral liquid was optimized by orthogonal experimental design. Results： The best optimized extracting condition was as follows; 10 times of water, to be extracted for three times, one hour for each time and 60% of alcohol precipitation concentration. Conclusion： The optimum process conditions are scientific and rational with high extraction efficiency, and stable and feasible.